These lectures, numbered 1 through 39 and three unnumbered, were delivered at Mr. Peale's Museum and are on such topics as natural history, physical phenomena and the elements, quadrupeds, fishes, birds, primates, and systems of identification. There are notes in the lectures for pauses, music, and illustrations to be included.

These letters and papers include a memorandum book (1795-1827), lectures on botany and medicine, genealogical materials, committee reports from Columbia College, speeches, minutes of the New York Horticultural Society (1822-1828), letters to Sir James Edward Smith (1817-1826), a receipt book of Alexander Hosack (1781-1801), and diaries of Thomas K. Wharton (1830-1862).